Thomas Dierks Selected Research

Multiple Sulfatase Deficiency Disease (Mucosulfatidosis)

9/2019	Severe neonatal multiple sulfatase deficiency presenting with hydrops fetalis in a preterm birth patient.
1/2018	Recognition and ER Quality Control of Misfolded Formylglycine-Generating Enzyme by Protein Disulfide Isomerase.
1/2018	Complex care of individuals with multiple sulfatase deficiency: Clinical cases and consensus statement.
1/2017	Expanding the genetic cause of multiple sulfatase deficiency: A novel SUMF1 variant in a patient displaying a severe late infantile form of the disease.
9/2013	Rapid degradation of an active formylglycine generating enzyme variant leads to a late infantile severe form of multiple sulfatase deficiency.
3/2011	SUMF1 mutations affecting stability and activity of formylglycine generating enzyme predict clinical outcome in multiple sulfatase deficiency.
8/2009	Neonatal manifestation of multiple sulfatase deficiency.
4/2009	Molecular basis of multiple sulfatase deficiency, mucolipidosis II/III and Niemann-Pick C1 disease - Lysosomal storage disorders caused by defects of non-lysosomal proteins.
1/2008	Molecular analysis of SUMF1 mutations: stability and residual activity of mutant formylglycine-generating enzyme determine disease severity in multiple sulfatase deficiency.
5/2007	Sulfatase modifying factor 1 trafficking through the cells: from endoplasmic reticulum to the endoplasmic reticulum.

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Thomas Dierks Research Topics

Disease

15	Multiple Sulfatase Deficiency Disease (Mucosulfatidosis) 09/2019 - 05/2003
7	Schizophrenia (Dementia Praecox) 01/2021 - 12/2007
6	Mucopolysaccharidoses 11/2020 - 06/2012
4	Neoplasms (Cancer) 11/2018 - 04/2008
4	Hallucinations (Hallucination) 01/2018 - 08/2011
3	Metachromatic Leukodystrophy (Sulfatide Lipidosis) 11/2020 - 03/2002
3	Gliosis 03/2016 - 07/2003
3	Lysosomal Storage Diseases (Lysosomal Storage Disease) 04/2015 - 10/2003
2	Usher Syndromes (Usher Syndrome) 01/2021 - 01/2018
2	Chondrodysplasia Punctata (Stippled Epiphyses) 11/2020 - 01/2018
2	X-Linked Ichthyosis (Ichthyosis, X Linked) 11/2020 - 01/2018
2	Metabolic Diseases (Metabolic Disease) 01/2020 - 01/2017
2	Atrophy 01/2018 - 07/2003
2	Mental Disorders (Mental Disorder) 01/2018 - 05/2007
2	Fibrosarcoma 01/2018 - 10/2014
2	Fucosidosis 01/2018 - 01/2016
2	Phobic Disorders (Phobia) 01/2017 - 05/2014
2	Starvation 06/2012 - 03/2004
1	Obsessive-Compulsive Disorder (Disorder, Obsessive-Compulsive) 01/2021
1	Bipolar Disorder (Manic Depressive Psychosis) 01/2021
1	Disease Progression 11/2020
1	Major Depressive Disorder (Major Depressive Disorders) 01/2020
1	Myocardial Infarction 10/2019
1	Infarction (Infarctions) 10/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018
1	Neuroinflammatory Diseases 01/2018
1	Psychotic Disorders (Schizoaffective Disorder) 01/2018
1	Scotoma (Scintillating Scotoma) 01/2018
1	Ovarian Neoplasms (Ovarian Cancer) 01/2017
1	Specific Phobia 01/2017
1	Anxiety Disorders (Anxiety Disorder) 01/2017
1	Retinal Degeneration 03/2016
1	Ataxia (Dyssynergia) 04/2015
1	Mucopolysaccharidosis III (Sanfilippo Syndrome) 04/2015
1	Acrophobia 05/2014
1	Arachnophobia 05/2014
1	Wounds and Injuries (Trauma) 01/2013
1	Spinal Cord Injuries (Spinal Cord Injury) 01/2013
1	Panic Disorder (Panic Attack) 01/2011
1	Mucolipidoses (Sialidosis) 04/2009
1	Alzheimer Disease (Alzheimer's Disease) 07/2003
1	Vascular Dementia (Subcortical Arteriosclerotic Encephalopathy) 07/2003

Drug/Important Bio-Agent (IBA)

14	EnzymesIBA 01/2021 - 05/2003
13	SulfatasesIBA 11/2020 - 04/2005
6	ArylsulfatasesIBA 01/2021 - 06/2012
5	N-formylglycineIBA 09/2013 - 05/2005
4	GlycosaminoglycansIBA 01/2020 - 08/2009
3	Pharmaceutical PreparationsIBA 08/2011 - 12/2007
2	Chondroitin Sulfates (Chondroitin Sulfate)IBA 01/2020 - 01/2013
2	Lysergic Acid Diethylamide (LSD)IBA 09/2019 - 01/2018
2	Proteins (Proteins, Gene)FDA Link 01/2018 - 06/2012
2	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2017 - 05/2014
2	LipidsIBA 01/2017 - 08/2009
2	GlucocorticoidsIBA 01/2017 - 05/2014
2	Sulfates (Sulfates, Inorganic)IBA 01/2017 - 01/2006
2	lysosomal proteinsIBA 03/2016 - 04/2009
2	Heparitin Sulfate (Heparan Sulfate)IBA 01/2013 - 06/2012
2	Antipsychotic Agents (Antipsychotics)IBA 08/2011 - 12/2007
2	C(alpha)-formylglycineIBA 10/2003 - 05/2003
1	Glucosamine (Dona)IBA 01/2021
1	salicylhydroxamic acid (SHAM)IBA 01/2021
1	MonosaccharidesIBA 01/2021
1	Glucuronic Acid (Glucuronate)IBA 01/2020
1	aminoquinuride (Surfen)IBA 10/2019
1	Urea (Carbamide)FDA LinkGeneric 10/2019
1	2-(2'-pyridyldithio)benzyldiazoacetateIBA 11/2018
1	Retinaldehyde (Retinal)IBA 01/2018
1	Mutant Proteins (Protein, Mutant)IBA 01/2018
1	Polytetrafluoroethylene (Teflon)FDA Link 01/2018
1	arachidonyltrifluoromethaneIBA 01/2017
1	Heparin (Liquaemin)FDA LinkGeneric 01/2017
1	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2017
1	alpha-L-Fucosidase (Fucosidase)IBA 01/2016
1	GlycoconjugatesIBA 01/2016
1	HydrolasesIBA 01/2016
1	GangliosidesIBA 04/2015
1	GlycolipidsIBA 04/2015
1	CholesterolIBA 04/2015
1	Mannose (D-Mannose)IBA 10/2014
1	N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA 01/2013
1	Chondroitin Sulfate ProteoglycansIBA 01/2013
1	BuffersIBA 01/2013
1	Chondroitin ABC LyaseIBA 01/2013
1	NitrogenaseIBA 06/2012
1	MolybdenumIBA 06/2012
1	AcidsIBA 08/2009
1	mutalipocin IIIBA 04/2009
1	AcetylglucosamineIBA 04/2009
1	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 05/2008
1	Psychotropic Drugs (Psychoactive Drugs)IBA 05/2007
1	EstersIBA 01/2006
1	SoilIBA 03/2004
1	SulfurIBA 03/2004
1	SteamIBA 07/2003
1	Inositol (Myoinositol)IBA 07/2003

Therapy/Procedure

3	Transcranial Direct Current Stimulation 01/2021 - 08/2011
3	Transcranial Magnetic Stimulation 01/2020 - 03/2013
3	Therapeutics 05/2014 - 03/2013
1	Neurofeedback 03/2018
1	Electrodes (Electrode) 08/2011